It's not so much that the Tunze nano can only handle smaller tanks, but it's more of a matter of the smaller footprint that can actually fit into a nano. The Tunze 3150 (standard) is definitely the better device overall (and the best ATO on the market, IMO), given it has dual sensors with one of them being optical. The other difference between the two is the 3150 goes into test mode every time the power is reset and it pumps for a bit (I believe 30 seconds), while the nano doesn't do this. The main reason being 30 seconds of top-off water into a nano could cause a significant SG swing.
For the record, I use the Tunze 3152 nano on my 14G and haven't had a single issue with it. It definitely would work on a larger tank (within reason) as well. With that being said, if the 3150 would fit and didn't go into test mode (I only give power to my ATO outlet for 30 seconds every half hour as a safeguard against the sensor getting stuck or the unit malfunctioning), I'd definitely use that.