Some things build up in certain situations
nitrate,
phosphate >>>> Should no longer be a problem. Various methods of filtration have actually created the need to dose these molecules.
certain metals >>>>>>> Significantly removed via algae growth and harvesting, for example.
sodium,
chloride >>>>> Will not occur if using a calcium reactor, kalkwasser or ionically balanced suppliments. ICP tests are now available to get exact figures on all major, minor & trace elements.
sulfate >>>>>>>>>>>> Occurs if using magnesium sulfate rather than magnesium chloride.
organics ????
virulent water column bacteria ????
It seems that the only good reason to do water changes, still, is for things that are not measurable at home - DOC, especially possible toxic forms, & virulent water column bacteria.
DOCs are certainly taken up by activated carbon, purigen, skimming & bacteria. But coelobite organisms such as sponges, tunicates, bryozoans, bivalves, and polychaetes, living in cryptic zones within a reef structure, take up & process massive amounts of DOCs & bacterioplankton. These types of organisms would exist in the display tank of a mature aquarium system to some degree. These types of organisms, introduced into a cryptic refugium, would be very effective at filtering - cycling & processing, these organics, I would be sure.
For those interested
https://www.researchgate.net/public...coral_reefs_the_cryptic_carbon_shunt_revealed
click on - Download full-text PDF, for easier to read layout.