It's not necessarily a huge problem, it's just that for most of us keeping the sand is more trouble than it's worth. The equation is a little bit different when moving a 20g tank than it is when moving a 300 gallon tank. For a larger, older tank, there's a lot more sand to speak of, and it's had more time to accumulate detritus. When you disturb the sand, many things that have been buried in your sand come to the surface and mix with your fresh, highly oxygenated water. This can lead to blooms of various types (ammonia, nitrate, phosphate, sulphur and more) and can spike a mini-cycle.
So on a larger tank, where you'd have to move hundreds of pounds of sand and could potentially set off a mini-cycle that could damage livestock, it's just easier to toss the sand. If you wanted to preserve your microfauna (like your nassarius babies), you'd take a few samples from your sand bed in different parts of the tank to "seed" the new sand with.