RNAi for fish and coral parasites

[themericks]

I apologize, this one may be way out there, but I have to ask. I was recently reading about RNA interference and its applications to fish disease. Some examples:

A RNAi-based therapeutic proof of concept targets salmonid whirling disease in vivo

Myxobolus cerebralis is a cnidarian-myxozoan parasite that causes salmonid whirling disease. M. cerebralis alternates between two hosts: (1) a vertebrate salmonid and (2) an invertebrate oligochaete, Tubifex tubifex. There is no successful treatment for salmonid whirling disease. MyxSP-1 is a M...

journals.plos.org

A new age in AquaMedicine: unconventional approach in studying aquatic diseases - BMC Veterinary Research

Background Marine and aquaculture industries are important sectors of the food production and global trade. Unfortunately, the fish food industry is challenged with a plethora of infectious pathogens. The freshwater and marine fish communities are rapidly incorporating novel and most up to date...

bmcvetres.biomedcentral.com

Exploring RNAi as a therapeutic strategy for controlling disease in aquaculture - PubMed

Aquatic animal diseases are one of the most significant constraints to the development and management of aquaculture worldwide. As a result, measures to combat diseases of fish and shellfish have assumed a high priority in many aquaculture-producing countries. RNA interference (RNAi), a natural...

pubmed.ncbi.nlm.nih.gov

I know next to nothing about RNAi, does anyone know if these sorts of treatment could one day make into the aquarium hobby? If so, is it a long way off or not? It sounds like this would be awesome for treating fish and coral parasites. Like I said, I know very little about this, hoping someone with more knowledge can give perspective.

 

[Jay Hemdal Verified Community Expert]

I apologize, this one may be way out there, but I have to ask. I was recently reading about RNA interference and its applications to fish disease. Some examples:

A RNAi-based therapeutic proof of concept targets salmonid whirling disease in vivo

Myxobolus cerebralis is a cnidarian-myxozoan parasite that causes salmonid whirling disease. M. cerebralis alternates between two hosts: (1) a vertebrate salmonid and (2) an invertebrate oligochaete, Tubifex tubifex. There is no successful treatment for salmonid whirling disease. MyxSP-1 is a M...

journals.plos.org

A new age in AquaMedicine: unconventional approach in studying aquatic diseases - BMC Veterinary Research

Background Marine and aquaculture industries are important sectors of the food production and global trade. Unfortunately, the fish food industry is challenged with a plethora of infectious pathogens. The freshwater and marine fish communities are rapidly incorporating novel and most up to date...

bmcvetres.biomedcentral.com

Exploring RNAi as a therapeutic strategy for controlling disease in aquaculture - PubMed

Aquatic animal diseases are one of the most significant constraints to the development and management of aquaculture worldwide. As a result, measures to combat diseases of fish and shellfish have assumed a high priority in many aquaculture-producing countries. RNA interference (RNAi), a natural...

pubmed.ncbi.nlm.nih.gov

I know next to nothing about RNAi, does anyone know if these sorts of treatment could one day make into the aquarium hobby? If so, is it a long way off or not? It sounds like this would be awesome for treating fish and coral parasites. Like I said, I know very little about this, hoping someone with more knowledge can give perspective.

I can’t speak to those studies, but if past history is any indication, I would not expect much, if any carryover from fisheries to aquariums. We are still in the dark ages, companies selling malachite green that hadn’t been used in aquaculture for decades. Even my go to copper treatment, Coppersafe, dates back to around 1980.

Aquarium companies now days don’t have disease R&D arms, their products are mostly old rehash of treatments.

Jay

 

[Chrisv.]

I mean why not just use cas9?