As a test, I purchased a 100-ft roll of 1/4" from Lowes, put a pressure gage on the RO/DI end and just ran it across the house as a temporary setup. When I noted how high the pressure was, I purchased the 3/8" PE and it dropped substantially. I think pulled the 3/8" through the attic. I have 1/4"x3/8" fittings on each end. I am getting ready to run 100-ft of line to connect my salt mixing tank behind the back of the house to aquarium and 35-ft from the RO/DI in the garage to the tank in the back. I am trying to see if I can do this through my soffits instead as they don't get as hot as the attic, but the attic provides better freeze protection. Since Im in the attic, I have a few safety provisions. I keep a drain valve on the end to drain the line when it is not in use; This is to not have the lines pressurized when they don't need to be. I also pulled this line inside of a 1/2" PE landscape hose (drip irrigation) as an outer sleeve. and to hopefully avoid any rodents from wanting to chew through them. Also, if the line were to bust or leak, the water would run to the end and either leak in my kitchen or my garage, but not over any of the rooms in between.