Currently I have an MP40 and MP60 on each side and a pair reefwave 45 gyre style pump on the back glass on either side of the overflow. If I were to swap out the gyres, I would probably keep the pumps on the back and for that reason I would add MP40s. The MP40s that I have on the sides are adequately sized, and I don't think there would be a benefit to having the broader flow of the MP60s. This is dependent on the aquascape though. I like the MP60 a lot, but I think the MP40s suit my specific application better. I have a friend with a tank measuring 84 x 33 x 26 who has four MP40s and two MP60s and he's happy with that combo.
Regarding flow, I continue to adjust, and I haven't found the right flow pattern yet. The challenge is due to the mixed reef, the difference in the flow requirements of many of the LPS, and more specifically how I had the corals laid out. I've changed how I have the acanthophylia and indophyllia arranged now and have them in a zone. Previously I had them mixed around, and I was turning down the pumps to avoid pushing their tissue around. This was contrary to my goal for the SPS, and having them all in a zone is working much better. It's a work in progress.