at the end of the day - almost every "nutrient" in your water ends up as No3 and po4, whether thru organism absorbing and expelling waste, bacterial conversion, chemical disolution, etc... so, effectively, if you have a good enough fuge, that's all you need - and there have been successful and mature tanks where fuge is the only method of nutrient export. It all just depends if you have enough biodiversity, stability, and patients to let your tank reach equilibriums in terms of how various organisms uptake nutrient in all these different stages (large particles, dissolved organics, proteim/amino chains) before they become No3/po4.