I just went through this situation. After a bunch of research and testing my results were inconclusive. The only way I have ever been able to tell if the glass is actually tempered or not is to simply start drilling. Unfortunately, that is not an acceptable answer.
The best test I found (not that it worked for me on my tempered tanks) was to use a computer/tablet screen and some polarized 3d glasses. Hold the screen inside the tank, and look through the glass (while wearing the glasses) at the screen. There are several YouTube videos about such tests.
That said, one of main reasons the glass is tempered is so the manufactures can use thinner glass. For example, my 65 gallon has 3/8" thick glass, and is not tempered, my 55 gallon has 1/4" glass and is tempered. My 220 gallon (not tempered) has 5/8" thick glass, while other 220 gallons I have seen have less than 1/2" thick glass. With this information, you can likely deduce whether it is tempered or not. However, the risk is still there that it is tempered.
If you are drilling the end of the tank and it breaks, the cost would be fairly low to replace that pane of glass. I know, not super helpful, I post this more to provide empathy, as this is a brutal dilemma for everyone who ever wants to drill a tank...