Extremely high nitrates (> 80 ppm) will have a cumulative negative effect on your fish over the long term. The first signs are typically lethargy and moderate loss of appetite.
As stated above and I agree, don't panic react, but instead set something in place to manage the increasing nitrates and then water changes to get the levels back down.
And never trust a single test kit. Do a backup test with another kit, and test your mixed fresh saltwater (assuming you are starting with RO water) for a comparison/control result.