You definitely can. I have about 25 different SPS, 15 LPS, and 15 different softies in the same tank. I feel like I am always making slight adjustments especially when I make new additions but that's part of the fun. Just arrange your rockwork so you have areas of high flow and low flow and also have places with high direct light and slightly more shaded areas. Of coarse the taller your tank, the easier it is to create those different environments. You also have to watch out for sweeper tentacles from those LPS as they can damage SPS extremely fast.