2 different circumstances requiring different flows (or selecting the right size UV to handle both). To damage/eliminate algae issues (dinos for ex) you need to have at least 8x flow to get ahead of reproduction rate and have at least 30,000 uw/cm2 exposure (the vendor should have the specs). To eliminate pathogens (ich/velvet) exposure at least 90,000 uw/cm2 (and some list up to 120,000 or more). So you'll have to do a little math on the flow rate at the different exposure rate (it's linear calculation so fairly straight forward - flow is proportional to exposure) to determine size you need.
You can go with one and a variable speed pump or big enough UV and fixed flow to cover both (8x flow at higher exposure rate - that becomes impractical with very large tanks) or two separate UVs and pumps (but who's going to do that, right?).
Manifold isn't optimal but it'll work. You're only taking a portion of tank flow so exposure rates are lower. Best to put in direct return line or closed loop. If have to be manifold maximize flow.