It's a very small concern, but generally, at least in the research that I could find, pex was more prone to bacterial growth than copper- I don't know about titanium. I wanted to err on the side of caution when telling people on the internet what to do.
"Warm water that is left stagnant can grow legionella, which can make humans seriously ill or dead. Legionella grows in stagnant water in pipes with temperatures below 113 degrees. Obviously, the danger is not too great, otherwise every time we left our plumbing idle for more than a couple days we would have problems. However, Pex is more prone to bacterial growth, and letting 100ft of pex sit at tank temperatures is a very good breeding ground for bacteria. These problems can be mitigated by daily flushing, but using a heat exchanger basically eliminates them."