I'm currently on dose #3 - going with the "dirty tank", plus the suggestion in the BRS videos about 2x a week, so my dose is 10ml every 5 days for my 105 (net) gal tank. Plus, as much manual removal as I can. Bubble algae is the WORST, plus some other fuzzy algae that's threatening my corals. So far, I think it's working though interestingly enough, BRS Ryan said theirs turned silver when it died. Mine's black, so hopefully it's not doing anything horrifying. I also dose BioDigest (other bacteria) so that may be contributing to the color of death, I don't know. My skimmer has an attack from the bacteria(s), but other than that, I don't have any issues with my sock filter or anything (I change that daily anyway). I have a pretty solid CUC, including a tiger conch, several kinds of snails, and a black long spine urchin.