Originally, I had planned (and currently have) a UV unit powerful enough that at high flow rates need for algae/bacteria - it produces enough wattage for sufficient exposure to kill pathogens. That way I don't need to adjust flow and I'm continually protected against both.
Two drawbacks to consider (and I'm still debating with myself on next setup).
1) It's more expensive - you have to buy bigger unit if you want to run system where you're protected against algae/bacteria and pathogens (or dinos and ich) all the time.
2) At the exposure to kill/damage pathogens - it's going to do the same to phytoplankton. Now, there's not a lot of phytoplankton in our tanks unless we add it (and it's not self sufficient so it always has to be added - as I understand it). But if you plan on adding phyto - you'll need to make sure your UV is set up for adjustable flow or turn it off. I don't ever plan on adding phyto - so pretty sure I'm going to go with being protected for both algae and phathogens but it is a consideration you should be aware of.
Don't mean to ramble on, but been thinking about this a lot last several weeks and helps to type it all out.