This is how I have my AquaUV 57-watt setup. Note the following:
* I run 4x 100-micron filter socks just outside the right edge of the image (where you see the ATO)
* I'm using the full width for the first post-filter chamber (bottom) which Red Sea labels "refugium". This allows me to run two MarinePure bio blocks in the center plus a bunch of the bio spheres to the immediate right (there's just enough room to pull out the filter sock trays).
* To the far left I have all my Neptune probes (temperature, salinity, ORP and ph).
Immediately to the right of the probes you'll see a braided hose snaking down (there's a Sicce SDC 6.0 pump that connects to it). This goes up to the AquaUV on the left and comes down the hose in the background that empties into the skimmer/reactor chamber (the return pump chamber is to the right of that below the ATO). I should point out that installing the UV upside down like this is not recommended and poses a few challenges to eliminate air bubbles (not insurmountable).
I estimate that the Sicce SDC 6.0 probably pulls in excess of 75% of the pre-filtered water which is diverted directly into the skimmer chamber (this comes down over the heaters and flows to the left - ensuring a nice circular flow pattern in that chamber. The other ~25% goes directly through the comb filter into the skimmer chamber where it's either run through the protein skimmer of pair of reactors.
The Sicce SDC 9.0 powering the main return runs @45%, and with a ~2.5m length works out to around 700 Gph. The Sicce SDC 6.0 powering the UV runs @45% as well, and based on a rough estimate of ~0.5m length works out to about 565 Gph. The specs from AquaUV indicate I can run up to 1,066 Gph (85%) and still get the maximum UV exposure of 90,000μ, so the actual radiation exposure is probably close to double.
While not ideal, if you're faced with stock plumbing for your tank - short of ripping apart the plumbing to install a manifold you don't have a lot of options. And what's interesting is that very few people run their UVs entirely off their return pump; most run a bypass at a reduced flow rate for the UV. And here's the kicker: Where do you think they drain it? Into either the skimmer or return pump chamber.
So wrap your head around that for a minute: most of the "proper" UV setups are actually re-sterilizing the same water over and over again - because they're diverting the return flow through the UV and then depositing it right back into the same or adjacent chamber. At least with my setup, while I fully admit that I'm probably not pulling more than 75% of the overflow through the UV - everything through the UV ends up in the skimmer chamber. So whether it subsequently runs through the skimmer or reactors (or goes straight into the return chamber), it's only being UV sterilized once - because it can't reverse flow back through the comb filter into the refugium chamber.
I did a bit of research on properly sizing your UV prior to installation, and while larger is always potentially better - the recommended hourly tank turnover is only something like 1-1.5x. I'm getting roughly 2.825x and in a pinch (say fish start showing signs of illness) I can ramp this up to 5.3x in just a few seconds. I personally wouldn't go as low as 1-1.5x, but I think anything in the 2.5-3x range (or higher) is perfect.