I have a 125 with 2, ... yes 2 Lifeguard 40 sterilizers. (One Lifeguard 40 is good for a 300 gallon) I have them plumbed together, right into my return chamber of the sump. The sterilizers are resting on top of the sump. The 2 sterilizers are plumbed together. I have a small pump in the return chamber, that pushes the water up and thru the 2 sterilizers, then the water gets dumped out thru the sterilizers, right back into my return chamber (where it is then returned back into the tank)
The pump I have moving the water into the sterilizers moves the water, just enough to get it thru the 2. You want to make sure that the water is taking its good old time going thru that sterilizer -- thus making it exposed to the UV rays for as long as possible, maximizing your "zapping time"