I highly, highly doubt it is palytoxin causing an allergic reaction to those people and is likely one of the other dozens of nasty things in our tanks. Palytoxin is a protein that binds to your cells sodium-potassium pump protein in place of ouabain and shuts down passive sodium and potassium transport through the cell membrane, destroying the ion gradient causing cell death. While it is
possible for aerosolized palytoxin to cause very severe flu like systems it is also doing lots of other damage to your body and any poisoning through an open cut or wound is going to be very serious, and
likely deadly due to the way it works. Death is caused by amounts measured in micgrograms or less.
The most common symtom of PTX poisioning is very, VERY nasty - a breakdown of skeletal muscle tissue and leaking of intracellular fluid into the bloodstream. This isn't something you recover from quickly like an allergic reaction by taking benadryll. It causes severe damage to muscular tissue, including the heart, so a poisoning would mean permanent or long-term damage.
I am sure there are hundreds, if not thousands, of things in our aquarium water you can be allergic to, but palytoxin isn't going to be one of them. I would be willing to bet most people who think they are poisoned by palytoxin are actually reacting to something else - any of the other countless substances, bacteria, viruses, and fungus thriving in our little systems.
The few cases of true, confirmed, palytoxin poisonings from reefs were all VERY serious. It is, afterall, the second most deadly non-peptide substance on the planet...
Here is a scientific article about it:
Palytoxin and Analogs: Biological and Ecological Effects - really interesting stuff and really freaking scary.