My Cura settings are very generic.
235-240c extruder temp.
50mm/s print speed. I usually never turn this up because it tends to cause other issues. I would rather just know it is going to print well every time then save 20 minutes.
Cooling turned off
5mm retraction & retract at the layer change
Brims on almost everything. Skirts sometimes when the model is really flat. I rarely use rafts.
100% infill because most of my models are thin-walled and won't function with infill. When I am not at 100% I will do 40-60% infill with cubic.
I just started using a.8mm nozzle and I wish I had switched to it a long time ago. The prints are coming out looking great and taking half the time. I would never utilize the build volume of the CR10 because the prints would take a week sometime. And when the print takes that long you are open up to a host of things that can go wrong. I had the power go out in my area one time and I was like 5 days into a 7-day print. I 100% recommend that you switch to a .8 nozzle
Last, I created a ****** enclosure for my printers by jamming foam sheet insulation into my garage shelving. If you don't already have an enclosure get a sheet of foam from home depot along with some acrylic. Your enclosed has to have a viewing window because you can lift the enclosure off before the print is finished. I've had some rapid cooling cause cracks in my prints because I checked them halfway.
Do you level the gantry? I just started doing this and my prints are turning out better and I have not had a fail since. I created these leveling blocks and just upload the designs to Thingiverse.
Cr10s leveling blocks
www.thingiverse.com