I currently run UV in my RS Max-500 (Turbo-Twist). I also run a smaller Turbo Twist on my office nano tank. Honestly I think one of the Pros to having a UV is that it does seem to polish the water nicely, add that to the shimmer of LEDs, gives you beautiful water to view thru. In the past I had some issues with "milky" algae blooms and a LFS suggested a UV to help clear it up. It cleared up and I have been using UV since then on different size tanks. Not being all that knowledgable about pathogens as others, I don't think its of much help to combat. Perhaps running one 24/7 might help more. I recently had an Ich outbreak and I hadn't got my UV hooked up yet prior to the outbreak, so not sure that it would have helped. After much reading on Reef2Reef and other blogs I learned that chemicals, UV etc...will not kill ich in your DT. If you have ich in your tank, you have to quarantine ALL fish for at least 30 days using a Cupramine soak and leave your tank fallow (no-fish) for up to 77 days to give you a 99.99% chance that you are rid of ich. One thing to consider as many will have opinions about Yes or No on a UV is that ALL Municipal Water Management facilities use UV in their final stages to combat any bad bacteria strains nasty microbe critters, prior to it running thru the city lines and out our tap. I'd say if it's safe to drink the water after UV treatment, it's prob safe for our fish...Unless you live in Flint Michigan....never drink the water there LOL Good luck in your decision!