My wife understands the scientific stuff and pointed me to a website that had this information:
Figure 57–1 Sites of action of antifungal drugs. Amphotericin B and other polyenes (e.g., nystatin) bind to ergosterol in fungal cell membranes and increase membrane permeability.
The imidazoles and triazoles (itraconazole, et al.) inhibit 14-α-sterol demethylase, prevent ergosterol synthesis, and lead to the accumulation of 14-α-methylsterols. The allylamines (e.g., naftifine and terbinafine) inhibit squalene epoxidase and prevent ergosterol synthesis. The echinocandins, such as caspofungin, inhibit the formation of glucans in the fungal cell wall.
I was explaining to her that some folks have good and fast results others do not. Her thoughts were that if the Fluconazole is either absorbed by the Bryopsis or GHA or something else in the tank, and not enough is available that could lead to slower or less than optimum results. Depending on how severe the outbreak is, the Flucon could be getting used up before it eliminates the algae. For people, it sounds as if there are cases where they load up and do a high dose for a few days and then cut back for the rest of the treatment period. So some people may need additional doses to fully eliminate it.
