I've now run fluconazole on two full reef sps dominated tanks and it works! I maintain aquariums and spent over a year fighting bryopsis and and quite a bit of hair algae to no avail. I added fluconazole at the rate of 20mg per gallon and only added it once on day one of the treatment. I removed the skimmer cup but kept the skimmer running. I removed carbon, chemipure etc. I didn't do any water changes for 14 days. My nutrient levels remained at their normal levels. The bryopsis starts dying a few days into the treatment. Those of you that have battled this plague know scavenging creatures seem to want nothing to do with bryopsis. That all changes during the fluconazole treatment. I began watching urchins, snails and crabs become hugely helpful, where once they simply were of no help. Urchins seemed particularly helpful. In my experience the bryopsis and hair algae died more rapidly in the highly lit areas of the tank first and then the shadowed areas. I've seen no impact on my corals or fish. I feed the tanks twice a day. I've never been a believer in a miracle cure. Prevention is the key! Bryopsis and hair algae began for me when I started using No3PO4X. I'm not saying they caused the outbreak as the timing may have been coincidental. I am saying in my case fluconazole definitely has worked. Up your cleanup crew, especially urchins. Stay the course for 14 days and then do your best to keep nutrients at appropriate levels. I bought the fluconazole at
www.payless-petproducts.com. Lastly, as you probably know fluconazole is the generic for the brand named drug diflucan. Generic meds can be plus or minus 10% of the active ingredient of the drug and the inactive ingredients can be totally different. That said, I've had success with the for mentioned fluconazole provider. To me it begs the question if others unsuccessful attempts with the drug have been because of the variance within the generic drugs themselves.
