The biggest thing to remember about safely dealing with palys and zoas is to never try to rid them from a rock by boiling, burning, scraping out of water, or anything extreme like that. Personally, I'd never risk it, although some people still do it, but use goggles, gloves, and a respirator in an open air space. The overwhelming majority of the palytoxin stories you read about are people trying to stop those big ugly old school brown palys from spreading on their rock work, so they take to extreme measures and end up releasing the palytoxin into the air.
It's definitely possible to have run-ins with palytoxin without doing any of those things, but not as likely, especially if you're not fragging and take basic safety precautions like disinfecting your hands after being in the tank.
