Thought I'd chime in here. I had a similar issues
Well I found the problem... For a recap I have a 1500 gallon + system made up of two large tanks. A 450G mixed reef upstairs and a 750G FOWLR in the basement. The sump, quarantine and frag tanks are also in the sump room. The 750 has one plank feeding pellets and the plank sits right on the...
www.reef2reef.com
My fish would have increased respirations prior to death and I found the my plank automatic feeder was full of saturated rotting food. The only a few fish survived including my purple tang. I also did massive water changes but I also removed all the rock, scrubbed and rinsed it. Removed and replaced the sand and refilled the system (1500 gallons). My fish were indeed quarantined and held in observation prior to adding. I'm sorry for your losses.
Just remember to add fish back slowly to allow you system time to adjust.