Hi Jay, I am currently using copper power. I had the fish in the tank roughly 10 days before I added copper but that is because I recently moved into a new home and I knew the fish were okay have owned for a while. If I were to purchase a new fish from the store/online I would observe and make sure they are eating for about 3-4 days then start copper. I did follow the instructions on the back. My system water volume is roughly 56 gallons I started with a dose of 1.25fl I was aiming for 1.00ppm copper. Result in the first dose was 1.02ppm so fairly close. After initial dose I waited 24 hours to ramp up to therapeutic levels I dosed 0.25fl each day until desired amount (2.25-2.50). I hope this helps if you have any other questions don’t hesitate to reach out!