I understand your concern with dosing chemicals but I would say it is more natural than some other chemicals on the market such as vibrant. NoPOX is a carbon source that feeds bacteria that consumes nitrates, then you skim out said bacteria. Give this article a read, it explains it much better than I can.
http://reefkeeping.com/issues/2008-08/nftt/
Also there is a concern for bacterial blooms if you dose nopox, because of this I dose a carbon source directly into a low flow reactor. I was able to bring down nitrates from 60ppm(at peak- it mostly hovered in the 40ppm range) down to under 10ppm and now I am on a maintenance(reduced) dosing schedule to keep my nitrates where I want.