I have a reactor with multiple small bags of ChemiPure Blue (GAC+resin). I change one out each month, so there is never the huge acute change that can precipitate RTN.
I also run ozone, with a controller. Look at the poll, so few people run ozone anymore. Too much hassle? Livestock or human safety concerns? Imagined inhibition of protein skimming? I'd say some people are missing out on a superb technique. When I first set this tank up, I ozonized aggressively, but gradually found that less and less ozone was need to maintain water quality and ORP at the same high level. Currently, with ozone running at 80 mg/hr for 5 minutes out of every hour (total 2 hours a day), my ORP runs around 350-400. I have never, not even once, observed any adverse reaction by any livestock that I was sure or even suspected was due to ozone toxicity; more than I can say for many of the other substances I've added at one time or another.
I used to run Purigen in the reactor, but eventually decided it was overkill, with the CP and ozone, so no longer using that. Ditto Poly Filter.
I do water changes with a white bucket so I can observe the tint of the water I've removed. With this regimen, it's always sparkly pale blue, like freshly mixed saltwater. Also, although the aquarium is heavily stocked and in a busy living space, and I feed generously several times a day, we never have that 'fishy' smell in the air that so many aquarists' homes have. Avoidance/elimination of that smell is one way that ozone really shines and something I very much appreciate.
Never had this issue. What generally causes it?
It creeps up on you; many people don't notice it at all until someone else points it out, because it develops so slowly. It's mostly due to
CDOM that builds up. German aquarists knew about it many years ago and called it
gelbstoff. In severe cases, it can substantially reduce the light reaching your corals, especially blue light which is actively absorbed by it. In fact, some people who've had it bad and removed it quickly wound up shocking their corals due to the sudden increase in illumination.
There are a few ways to test for it. If you have a long tank, you can tape a piece of bright white printer paper up on one end and look at it from the other end. If it has any yellowish tinge at all, there's your answer. Hanna also sells a
Color of Water Checker, which measures this yellow discoloration. I assume it's sensitive but I don't know for sure because I've only ever gotten a reading of 0 with mine. The included sealed standard vial however does give me the right reading.
I used ozone many years ago (about 30ish) since the last 25 years or so I have used Oxydators which are far simpler and easy to use, cheap and safe, no controller required. Have worked great for me all these years, I wouldn't go back to ozone.
I've heard others say these things are good but I've also read where some felt they were responsible for problems. It would be interesting to try some time.