Metronidazole, an effective antiprotozoal agent, was the drug of choice in this outbreak because it is well tolerated by sensitive fishes such as seahorses and because its liposolubility allows it to penetrate into internal organs. Metronidazole has a high intestinal absorption rate, resulting in distribution of the drug into all tissues.
This makes it effective against intestinal as well as tissue parasites.
Because of the anorexia observed in the infected seahorses, oral administration was not an option. Additionally, forced alimentation was difficult to perform because of the small buccal apparatus of the seahorse. Finally, prolonged handling could add further stress to weakened animals. Bath therapy was the method of choice because the
drug would likely have been effective against freeliving, epidermal and internal ciliates. As a bath, metronidazole would pass through the gill epithelium and diffuse into all tissues.