With the normal 75 GPD RO membrane at the recommended 4:1 waste ratio you are flowing 375 GPD or right at 1 quart or 32 oz per minute. The friction or headloss in a 1/4" line at that velocity is pretty high so you lose a lot before it gets to the other end.
You want to maintain 60 psi or greater on a RO membrane if possible for optimal performance, 40 is the bare minimum and the rejection rate or removal efficiency at that pressure is much lower so TDS is higher and DI exhausts sooner.
Keep your line lengths to a minimum, especially on the input or tap water side as any pressure drop has drastic effects on rejection rate and GPD production rate. If I take the same 75 GPD RO membrane which produces 75 GPD at 50 psi and 77 degrees F water temperature and reduce the pressure to 40 psi I am now at only 58 GPD and my rejection rate has probably dropped 2-3%. Bump it up to 60 psi and it produces 90 GPD and my rejection rate is probably 98%.
Heat and cold also have huge effects on RO systems, they cannot take anything above 113 degrees F or it damages the thin film membrane so running exterior lines or mounting it outside is not a good idea. Cold water actually treats better so produces lower TDS but it will reduce the GPD. Warm water is more fluid so passes through the membrane faster meaning higher GPD but it also carries more contaminants through so higher RO TDS and shorter DI life.
Also, when you lengthen the waste line to the drain you change the recommended 4:1 waste ratio so could be damaging the RO membrane due to insufficient continuous flushing the flow restrictor provides. If you run a long waste line make darn sure you check and adjust the waste ratio after installing thesystem or you may have short membrane life.
Keep the line lengths to a minimum. If you must run over say 40-50 feet then step up to 3/8" tubing for the tap water intake line, its readily available at any hardware store and flows much more than the standard 1/4" so has lower headloss. Always monitor your RO membrane pressure looking for signs of headloss or sediment filter plugging and occasionally check the waste ratio as it can change with time and plug a membrane in a heartbeat. Been there done that, once you stick it in a drain you forget it and thats not good. Membranes get expensive.