We have to remember, that origional rock from the ocean has 100's to 1,000's of years in the reefs to gain bacteria, way deep in the rock, where as the man made rock does not, and never will. In time it can cover the surface. The hope we have, is rock that is farmed in the ocean for our hobby and public aquariums, as it is packed with bacteria. But, I've seen that rock that has been cultivating for several years, that when cut in half it's pure white, with very little life. Like mentioned, live sand can be very rich in bacteria and critters,....good and bad, mind you, as there's pro'& con's of a deep sand bed, of at least 3" depending on the size of tank.
I've never went deeper than 6" and that was a system measured of biologist Alf Jacob Nilsen's nitrifying/denitrifying bacteria sandbed and screened 4" of plenum. I used it in my 75g reef and 40g breeder for clams, and it was amazing on how well it worked, even with a high fish load. No skimmer, no filter products and had less than 15 nitrate no phosphates in 3 years. I may set up my 93g cube using the same method using all dead rock, as a clown hosted anemone tank.