I had something similar in my frag tank over the past year. I always suspected a pathogen, but the Aquabiomics tests were not available here until recently. I plan to test the tank just to see if there is a bacterial cause.
In the meantime, I have been using Dr. Tim's, Color Up Your Corals recipe, to dose Eco-Balance on a daily basis. I follow the suggested schedule, so it doses 5 days a week. This recipe is intended to help weak, pale, struggling corals, but since it is based on Eco-Balance, and Eco-Balance is claimed to have some protection against Vibrio, I thought I would try it.
In the past, the tissue necrosis seemed to be tied to or driven by nitrate levels. The tank is running super low nitrate (0.2), but in the past whenever I would dose to raise it, the RTN disease would manifest and wipe out random corals. It also seemed to be passed to neighbouring corals. Eventually I just stopped trying to raise nitrate, just due to the amount of losses that it would lead to.
After running the Dr. Tim's recipe for a few months, I have started doing a daily nitrate dose. A very minor 0.25 ppm per day, and recently bumped to 0.50 ppm per day. So far, so good, no return of the RTN yet. I will still get the test to see what if any is present in the tank.