Tired, good questions and I think I can explain what is "my opinion" which I came upon many years ago from doing this and SCUBA diving.
Fish in the sea are for the most part immune. If they were not, there would be no fish, just like sharks eat fish, but they don't eat all the fish.
Remember, fish in the sea eat other fish, parasites and all.
As you mentioned fish in the sea get stressed. They get old, get bitten, get hot, cold or can't find enough food. Those fish are then preyed upon by parasites because their immunity is weakened.
In my tank, if a fish is dying from something besides disease such as jumping out or old age, before they die, they will probably exhibit parasites. This is normal because that fish has a compromised immunity just like someone on cancer drugs.
"Most" people in Mexico or Viet Nam don't get sick if they live in civilized conditions. If they did, there would be no people there as their immunity keeps them well for the most part.
In the middle ages a third of Europe died from the Plague. But not everyone died as they became immune. As a matter of fact, many people today who are immune from Aids is because their ancestors survived the Plague and their family lived on. Now we know that many of the deaths from the Plague was actually viral and not bacterial.
(and, no, I am not going to look that up)
The Europeans were not already immune from the Plague because it came from China on the "Silk Road". It actually started on (I think) gerbils but after most of the gerbils died, it jumped to rats. Who knew?
(I took a long class on that and found it interesting about the Aids)
But anyway, the people gradually became immune.
We get Covid, which I have now because I wasn't brought up with Covid as it was probably made in a lab or came from bats in China, depending on who you believe.
Parasites in the sea stay alive by feasting on the sick, stressed and old fish in the sea. I have been diving 60 years and have never seen ich or velvet on a wild fish, but I know parasites are all over the place.
(buzzards, which can be considered parasites of a "sort" eat dead or dying animals and live fine while they are waiting for that meal)
In my own tank I know there must be parasites living happily with my fish. In the 51 years my tank has been running I have put probably dozens of infected fish in there from every LFS in new York and another dozen or so from the sea.
I collect water from the sea and after warming it up, dump it in my tank.. I have always done this and it is documented on these forums since they started.
If living around a disease automatically makes you immune,
Living around disease doesn't automatically make you do anything. You may die before your body can make an antibody. But your body is making them. Some diseases are so virulent that your body just can't pump out antibodies fast enough.
Fish from the sea have immunity as they are living, eating and breathing parasites constantly. It is true that after we put them in our tanks they are exposed to different diseases from different oceans but the fish will still make antibodies. It just may take a while but they are making them.
If the fish is kept healthy and stress free as much as possible, that fish will have no problem fending off a parasite.
Fish have slime for that main reason. The slime, besides containing antibodies for pathogens is also water soluble so as the fish swims, the slime sloughs off. That is the first line of defense for a fish.
There are a few scientific studies on immunity on fish and you can find some on line such as this one. I researched all of these studies as I was researching for my book and didn't actually make all of this up on my own.
I know people like scientific studies so here is part of one. You can search the entire article if you like as well as many more and not just fish sites where we get opinion.
Ref: Copyright © 2012 María Ángeles Esteban. This is an open access article distributed under the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
(ISRN ImmunologyVolume 2012 (2012), Article ID 853470, 29 pageshttp://dx.doi.org/10.5402/2012/853470Review Article
An Overview of the Immunological Defenses in Fish SkinMaría Ángeles Esteban)
Quote: Immunity associated with the parasites depends on the inhabiting discrete sites in the host. Especially important for this paper are the ectoparasites, those habiting in or on the skin. Until recently there had been little direct evidence of innate immune mechanisms against parasites associated with mucosal epithelium [
285].
The active immunological role of skin against parasitic infection has been shown recently [
286–
288], and now mucosal immunity against them start to be elucidated.
Non-parasitic fishes usually die following infection, but animals surviving sublethal parasite exposure become resistant to subsequent challenge. This resistance correlates with the presence of humoral antibodies in the sera and cutaneous mucus of immune fishes.
According to these authors "probiotic for aquaculture is a live, dead or component of a microbial cell that, when administered via the feed or to the rearing water, benefits the host by improving either disease resistance, health status, growth performance, feed utilisation, stress response or general vigour, which is achieved at least in part via improving the hosts or the environmental microbial balance."The first demonstration that probiotics can protect fishes against surface infections was against
Aeromonas bestiarum and
Ichthyophthirius multifiliis in rainbow trout [
330]. The research on this topic is considered of high priority at present because enriched diets could be used as preventive or curative therapies for farmed fishes. End Quote
Another one.
Coincidently in this months "Popular Science" (August 2015) there is an article about this very topic. The author states that the most germ free envirnment today is on the International Space Station. Everything is sterilized including the air. All the surfaces are coated with bacteria limiting coatings, even the water is treated with iodine and biocidal nano silver so the only bacteria prsent are the ones coming from the astronauts themselves. End Quote
They can't open a window or send out for Pizza so there is no fresh influx of microbes to balance the ecosystem. Sounds like quarantining doesn't it? He also states that a loss of gut bacteria correlates with many diseases and could impede longer space travel. If we lose our gut bacteria, our immune system goes dormant.