Just want to throw out a pro/con of closed loops vice powerheads base on my tank (6ft long) with an MP40 on each end.
The advantage of powerheads is that the impellers, by their nature, create more turbulent flow on their output. You can replicate this to a small extent with a closed loop but that is it.
I typically run my MP40's at 25oo gph. They really only have an effective reach 24" into the tank. By 36" the flow is fairly minor. Not a concern for me since the center of my tank is empty space. I count that as 5000gph of total flow in my system.
Lets say I'm running a closed loop with the suction and discharge on opposite ends. If I have 2500 gph on one end then I have to have 2500 gph on the opposite end. In effect, I have just as much total system flow (if not more) than the 5000 gph from my 2 MP40's.